.: Peer Reviewed Publications

1. Mehmet Sen and Glen B. Legge. “Pactolus I-domain: Functional Switching of the Rossmann Fold” Proteins, 2007, 68(3): 626-635. PDF.

2. Mehmet Sen, Mark Herzik, Jr., John W. Craft, Jr., Andrea L. Creath, Sameer Agrawal, Wolfram Ruf, and Glen B. Legge. (2007) “Spectroscopic Characterization of Successive Phosphorylation of the Tissue Factor Cytoplasmic Region“ The Open Spectroscopy Journal, 2009, 3:58-64. PDF.

3. Roberto Carreño, Dan Li, Mehmet Sen, Iris Nira, Tatsuo Yamakawa, Qing Ma, and Glen B. Legge. “A mechanism for antibody-mediated outside-in activation of LFA-1” Journal of biological chemistry, 2008, 283(16): 10642-8. PDF.

4. Yang Wang, Dan Li, Roza Nurieva, Justin Yang, Mehmet Sen, Roberto Carreño, Sijie Lu, Bradley W. McIntyre, Jeffrey J. Molldrem, Glen B. Legge and Qing Ma. “LFA-1 Affinity Regulation Is Necessary for the Activation and Proliferation of Naive T Cells” Journal of biological chemistry, 2009, 284(19): 12645-53. PDF.

5. Koichi Yuki, Weiming Bu, Jin Xi, Mehmet Sen, Motomu Shimaoka and Roderic G. Eckenhoff. “Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1” The FASEB Journal, 2012, 26(11): 4408-17. PDF.

6. Mehmet Sen, Koichi Yuki, Timothy A. Springer. “An internal ligand-bound, metastable state of a leukocyte integrin”, Journal of Cell Biology, 2013, 203 (4): 629. PDF.

7. Florencia Rosetti, Yunfeng Chen, Mehmet Sen, Cheng Zhu, Tanya N. Mayadas. “Role for a lupus-associated variant in the β-propeller domain of Mac-1 in mechanical reinforcement of integrin interactions with ligand”, Cell Reports. 2015, S2211-1247(15)00183-7. PDF.

.: Patents

1. Drug discovery platform using stabilized low affinity conformation of integrins: U.S. Serial No. US 2010/0167418 (http://www.childrensinnovations.org/SearchDetails.aspx?id=2092)