Publications

  1. Home
  2. Research
  3. Publications

Publications

  1. Saggu G, Okubo K, Chen Y, Vattepu R, Tsuboi N, Rosetti F, Cullere X, Washburn N, Tahir S, Rosado AM, Holland SM, Anthony RM, Şen M, Zhu C & Mayadas TN. "Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment". Nat Commun, 9(1): 5058, 2018. PMID: 30498196.
  2. Kurakula K, Koenis DS, Herzik MA Jr., Liu Y, Craft JW Jr., van Loenen PB, Vos M, Tran MK, Versteeg HH, Goumans MTH, Ruf W, de Vries CJM & Şen M. "Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity". Haematologica, 103(6): 1073–82, 2018. PMID: 29545340.
  3. Şen M, Koksal AC, Yuki K, Wang J & Springer TA. "Ligand and cation-induced structural alterations of the leukocyte integrin LFA-1". J Biol Chem, 293(17): 6565–77, 2018. PMID: 29507098.
  4. Hiramitsu S, Ishikawa T, Lee WR, Khan T, Crumbley C, Khwaja N, Zamanian F, Ashgari A, Şen M, Zhang Y, Hawse JR, Minna JD & Umetani M. "Estrogen receptor beta-mediated modulation of lung cancer cell proliferation by 27-hydroxycholesterol". Front Endocrinol, 9: 470, 2018. PMID: 30190703.
  5. Wilson ZS, Ahn LB, Serratelli WS, Belley MD, Lomas-Neira J, Şen M & Lefort CT. "Activated β2 integrins restrict neutrophil recruitment during murine acute pseudomonal pneumonia". Am J Respir Cell Mol Biol, 56(5): 620–7, 2017. PMID: 28157452.
  6. Manandhar P, Abousaway O, Le T & Şen M. "Role of structural dynamics in leukocyte integrins function: interplay between the shape-shifting mechanism and allostery". Int J Cell Sci & Mol Biol, 3(4), 2017.
  7. Şen M & Springer TA. "Leukocyte integrin αLβ2 headpiece structures: the αI domain, the pocket for the internal ligand, and concerted movements of its loops". PNAS, 113(11): 2940–5, 2016. PMID: 26936951.
  8. Rosetti F, Chen Y, Şen M, Thayer E, Azcutia V, Herter JM, Luscinskas FW, Cullere X, Zhu C & Mayadas TN. "A lupus-associated Mac-1 variant has defects in integrin allostery and interaction with ligands under force". Cell Rep, S2211-1247(15)00183-7, 2015. PMID: 25772353.
  9. Şen M, Yuki K, & Springer TA. "An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2". J Cell Bio, 203(4): 629, 2013. PMID: 24385486.
  10. Yuki K, Şen M & Springer TA. "Common activation mechanism of beta 2 integrins (P5073)". J Immunol, 190(1 Supplement): 129.1, 2013.
  11. Yuki K, Bu W, Xi J, Şen M, Shimaoka M & Eckenhoff RG. "Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1". FASEB J, 26(11): 4408–17, 2012. PMID: 22815384.
  12. Wang Y, Li D, Nurieva R, Yang J, Şen M, Carreño R, Lu S, McIntyre BW, Molldrem JJ, Legge GB & Ma Q. "LFA-1 affinity regulation is necessary for the activation and proliferation of naive T cells". J Biol Chem, 284(19): 12645–53, 2009. PMID: 19297325.
  13. Şen M, Herzik MA Jr., Craft JW Jr., Creath AL, Agrawal S, Ruf W & Legge GB. "Spectroscopic characterization of successive phosphorylation of the tissue factor cytoplasmic region". Open Spectrosc J, 3: 58–64, 2009. PMID: 20076769.
  14. Carreño R, Li D, Şen M, Nira I, Yamakawa T, Ma Q & Legge GB. "A mechanism for antibody-mediated outside-in activation of LFA-1". J Biol Chem, 283(16): 10642–8, 2008. PMID: 18199751.
  15. Şen M & Legge GB. "Pactolus I-domain: functional switching of the Rossmann fold". Proteins, 68(3): 626–35, 2007. PMID: 17523188.

Posters

Bold — poster presenter. — awarded.

  1. Castillo M, Şen M & Kayser V. Utilizing N-glycans to develop aggregation resistant monoclonal antibodies. 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
  2. Manandhar P, Liu Y, Rajarathnam K, Yuki K, Briggs J & Şen M. Molecular basis of simvastatin binding to integrin αXβ2. 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
  3. Abousaway O, Aboagye C, Rajarathnam K & Şen M. Triple resonance NMR backbone assignment of the ligand binding domain of the αXβ2 integrin. 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
  4. Moussa Z, Mazhar Z, Yuki K, Briggs J & Şen M. Identifying an activating glycan mutant in αX subunit of αXβ2 integrin. 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
  5. Bodunrin A, Wang T, Şen M & Widger W. Biophysical & structure properties of the UspA712 of Micrococcus luteus. 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
  6. Fannin S, Rangel J, Widger W & Şen M. Purification and initial characterization of a hypothetical membrane protein. 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
  7. Rangel J, Şen M & Widger W. Can activation of Rho factor through RNA binding-induced ring closure be identified by cryo-EM? 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
  8. Dairywala M, Manandhar P, Aboagye C, Yu T & Şen M. Structural characterization of leukocyte integrin αM I-domain. Undergraduate Research Day, University of Houston, Houston, TX, October 2018.
  9. Manandhar P, Aboagye C, Le T & Şen M. Probing conformational changes and stability of the ligand binding site of integrin αXβ2. 23rd Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, April 2018.